Ezh2 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comEzh2 Polyclonal Antibody for Mouse(Mus musculus)

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Ezh2 (Gene name),

Histone-lysine N-methyltransferase EZH2 (Protein name ), EZH2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ezh2(Enx1h);

Protein name:

Histone-lysine N-methyltransferase EZH2;

Alternative:

Enhancer of zeste homolog 2;ENX-1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2 (By similarity). The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12 (By similarity). The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit (By similarity). Interacts with HDAC1 and HDAC2 (By similarity). Binds ATRX via the SET domain (By similarity). Interacts with PRAME (By similarity). Interacts with EED.

Function:

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8.

Subcellular Location:

Nucleus Chromosome Localizes to the inactive X chromosome in trophoblast stem cells.

Protein Attributes:

Sequence length:

746

Sequence:

50:

100:

150:

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250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

746:

MVNGDHRIGI | FAKRAIQTGE | ELFFDYRYSQ | ADALKYVGIE | REMEIP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q61188

Pfam:

PF11616

UniGene:

Mm.246688

KEGG:

mmu:14056

String:

Q61188

Uniprot:

Q61188

FOR

ELISA Kit for Mouse Histone-lysine N-methyltransferase EZH2

Cat.:

E7688h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Mouse Histone-lysine N-methyltransferase EZH2

Cat.:

E7688m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Histone-lysine N-methyltransferase EZH2

Cat.:

U7688m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Histone-lysine N-methyltransferase EZH2

Cat.:

U7688h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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Polyclonal Antibody for Mouse Histone-lysine N-methyltransferase EZH2

Cat.:

P7688Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Histone-lysine N-methyltransferase EZH2

Cat.:

P7688Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Histone-lysine N-methyltransferase EZH2

Protein for Mouse Histone-lysine N-methyltransferase EZH2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene."
Hobert O. , Sures I. , Ciossek T. , Fuchs M. , Ullrich A.
Mech. Dev.55:171-184(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Placenta.
2.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Czech II.
tissue: Mammary tumor.
4.

"The murine polycomb-group genes ezh1 and ezh2 map close to hox gene clusters on mouse chromosomes 11 and 6."
Laible G. , Haynes A.R. , Lebersorger A. , O'Carroll D. , Mattei M.-G. , Denny P. , Brown S.D.M. , Jenuwein T.
Mamm. Genome10:311-314(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-497
strain: 129/Sv.
5.

"Point mutations in the WD40 domain of Eed block its interaction with Ezh2."
Denisenko O.N. , Shnyreva M. , Suzuki H. , Bomsztyk K.
Mol. Cell. Biol.18:5634-5642(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EED
6.

"The polycomb-group gene Ezh2 is required for early mouse development."
O'Carroll D. , Erhardt S. , Pagani M. , Barton S.C. , Surani M.A. , Jenuwein T.
Mol. Cell. Biol.21:4330-4336(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
7.

"Mitotically stable association of polycomb group proteins Eed and Enx1 with the inactive X chromosome in trophoblast stem cells."
Mak W. , Baxter J. , Silva J. , Newall A.E. , Otte A.P. , Brockdorff N.
Curr. Biol.12:1016-1020(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
8.

"Establishment of histone H3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes."
Silva J. , Mak W. , Zvetkova I. , Appanah R. , Nesterova T.B. , Webster Z. , Peters A.H.F.M. , Jenuwein T. , Otte A.P. , Brockdorff N.
Dev. Cell4:481-495(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
9.

"Role of histone H3 lysine 27 methylation in X inactivation."
Plath K. , Fang J. , Mlynarczyk-Evans S.K. , Cao R. , Worringer K.A. , Wang H. , de la Cruz C.C. , Otte A.P. , Panning B. , Zhang Y.
Science300:131-135(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
10.

"The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation."
Caretti G. , Di Padova M. , Micales B. , Lyons G.E. , Sartorelli V.
Genes Dev.18:2627-2638(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

Caretti G. , Di Padova M. , Micales B. , Lyons G.E. , Sartorelli V.
Genes Dev.19:768-768(2005)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
12.

"Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes."
Umlauf D. , Goto Y. , Cao R. , Cerqueira F. , Wagschal A. , Zhang Y. , Feil R.
Nat. Genet.36:1296-1300(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Reactivation of the paternal X chromosome in early mouse embryos."
Mak W. , Nesterova T.B. , de Napoles M. , Appanah R. , Yamanaka S. , Otte A.P. , Brockdorff N.
Science303:666-669(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
14.

"Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation."
Kuzmichev A. , Margueron R. , Vaquero A. , Preissner T.S. , Scher M. , Kirmizis A. , Ouyang X. , Brockdorff N. , Abate-Shen C. , Farnham P.J. , Reinberg D.
Proc. Natl. Acad. Sci. U.S.A.102:1859-1864(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
15.

"The polycomb group protein EZH2 is required for mammalian circadian clock function."
Etchegaray J.P. , Yang X. , DeBruyne J.P. , Peters A.H. , Weaver D.R. , Jenuwein T. , Reppert S.M.
J. Biol. Chem.281:21209-21215(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CLOCK; ARNTL AND CRY1
16.

"The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation."
Kalantry S. , Mills K.C. , Yee D. , Otte A.P. , Panning B. , Magnuson T.
Nat. Cell Biol.8:195-202(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
17.

"The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells."
Bracken A.P. , Kleine-Kohlbrecher D. , Dietrich N. , Pasini D. , Gargiulo G. , Beekman C. , Theilgaard-Moench K. , Minucci S. , Porse B.T. , Marine J.-C. , Hansen K.H. , Helin K.
Genes Dev.21:525-530(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
18.

"Developmental regulation of Eed complex composition governs a switch in global histone modification in brain."
Kim S.Y. , Levenson J.M. , Korsmeyer S. , Sweatt J.D. , Schumacher A.
J. Biol. Chem.282:9962-9972(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EED
19.

"MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis."
Wong C.F. , Tellam R.L.
J. Biol. Chem.283:9836-9843(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INDUCTION
20.

"EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency."
Shen X. , Liu Y. , Hsu Y.-J. , Fujiwara Y. , Kim J. , Mao X. , Yuan G.-C. , Orkin S.H.
Mol. Cell32:491-502(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE PRC2/EED-EZH1 COMPLEX
21.

"Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms."
Margueron R. , Li G. , Sarma K. , Blais A. , Zavadil J. , Woodcock C.L. , Dynlacht B.D. , Reinberg D.
Mol. Cell32:503-518(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
22.

"Role of hPHF1 in H3K27 methylation and Hox gene silencing."
Cao R. , Wang H. , He J. , Erdjument-Bromage H. , Tempst P. , Zhang Y.
Mol. Cell. Biol.28:1862-1872(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
23.

"Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation."
Walker E. , Chang W.Y. , Hunkapiller J. , Cagney G. , Garcha K. , Torchia J. , Krogan N.J. , Reiter J.F. , Stanford W.L.
Cell Stem Cell6:153-166(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE PRC2 COMPLEX
24.

"Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes."
Nguyen K.D. , Fentress S.J. , Qiu Y. , Yun K. , Cox J.S. , Chawla A.
Science341:1483-1488(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARNTL/BMAL1
25.

"Structural basis of EZH2 recognition by EED."
Han Z. , Xing X. , Hu M. , Zhang Y. , Liu P. , Chai J.
Structure15:1306-1315(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) OF 39-68 IN COMPLEX WITH EED;INTERACTION WITH EED;MUTAGENESIS OF PHE-42; ASN-45; ILE-49; LEU-56; PRO-67 AND VAL-68

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